Long-Range Research Initiative (LRI)

The Long-Range Research Initiative (LRI) of the American Chemistry Council (ACC) promotes innovations in chemical safety assessment. It invests in science essential for understanding the impact of chemicals on human health and the environment.

With a focus on biologically-relevant exposures, LRI adopts an integrated approach to exposure and hazard characterization to promote a shift in focus away from development of safety assessments based solely on hazard or exposure data.

Through integration and translation of its research outcomes, LRI transforms this information into knowledge that can inform decisions and policies about the safety of chemicals relevant to current environmental and public health challenges.

Three female researchers working together.

Research Strategies

The LRI Research Strategy provides the framework for development of more detailed research plans that align with health and environmental issues of highest priority to society and the chemistry industry.

Colorful Science Laboratory

LRI: Science for a Sustainable Future

The importance of science to decision making about chemical safety is more evident today than ever before. Demands are increasingly heard for science that can drive decisions to improve human health and the environment.

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Long-Range Research Initiative (LRI) Catalog

Collaborating Organization(s): Charles River Laboratories, MatTek Corporation, Greek Creek Toxicokinetics Consulting LLC

Keywords: 2D and 3D lung models, inhaled chemical safety assessment, in vitro, human, rat, computational methods, modeling, validation

Authors: Wallace J, McElroy MC, Klausner M, Corley R, Ayehunie S

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Dr. Richard Becker